Utility of hydrazonoyl halides as precursors for synthesis of novel antitumor pyrazolo [3,4-d] pyrimidine derivatives

Novel substituted pyrazolo[3,4-d]pyrimidine-4,6-dione [5a-j] have been prepared by reacting 1,3-dimethylbarbituric acid 1 with hydrazonoyl chloride [2a-j].The cytotoxicity [SRB assay using tumor cells] of compounds 5c,e against liver [HEPG2] and breast carcinoma [MCF7] cell lines revealed that 5c was more efficient than the standard drug [Doxorubicin]

one pot regioselective synthesis of new functionalized derivatives of [1, 2, 4] triazolo

Reaction of S-cyano-6-aryl-2-thiouracil 1A-C or its methylthio derivatives 2A-C with hydrazonoyl chlorides 3a-h led to the formation of 7-atyl-6-cyano-1, 2, 4-triazolo [4, 3-alpha] pyrimidin-5 [1H]-one derivatives 8. The mechanism and the regioselectivity of the studied reactions were discussed with the help of the given X-ray crystallographic data

Photochemical synthesis and antimicrobial activities of 1 -phenyl-3-[2-thienyl]-pyrazoline derivatives

Irradiation of 2-phenyl-5-[2-thienyi]-tetrazole 1 with acrylate derivatives 2A-E [molar ratio 1:1] in anhydrous benzene gave the corresponding title compounds 1-phenyl-3-[2-thienyl]-pyrazoline derivatives 4A-E as end products. The mechanism and the regiochemistry of the studied reactions are discussed